He was nominated for the Independent Spirit Award for Best Supporting Male for his performance in End of Watch.
Peña was born in Chicago, Illinois, the son of Nicolasa, a social worker, and Eleuterio Peña, a factory worker. Peña's parents were originally farmers, and emigrated from Mexico; his father was from Villa Purificación, Jalisco, and his mother was from Charcas, San Luis Potosí. He grew up in the North Lawndale area and attended Marist High School, and graduated from Hubbard High School where he participated and was a state qualifier in wrestling and track. He attended St. Nicholas of Tolentine Elementary.
Though Peña has been a regular in independent productions since 1994, his breakthrough performances came in two Best Picture Oscar-winning Paul Haggis-penned films, Million Dollar Baby (2004) and Crash (2004). The former was directed by Clint Eastwood, and the latter was directed by Haggis. Though both films are critically acclaimed, Peña received attention for his particularly emotional performance in Crash. The following year, he appeared on the Golden Globe-winning series The Shield. he starred in Oliver Stone's film based on the September 11, 2001 attacks, World Trade Center. He also had a small role in Alejandro González Iñárritu's film Babel. This gives him the rare distinction of having appeared in three consecutive Oscar-nominated films.

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