DiStefano's earliest band, K-38, released a single, "For Those Who Listen", in 1986.
He formed Porno for Pyros in 1992 with Farrell, Perkins and bassist Martyn LeNoble. During their successful five-year run, the band's eponymous first album hit No. 3 on the Billboard 200, earning gold. In 1997, the band went on hiatus after DiStefano was diagnosed with testicular cancer.
DiStefano recovered from cancer and heroin addiction in July 1997. He later independently released the solo albums Gratitude in 2004 on Sanctuary Records, and Loyalty in 2007 on Lonely Seal Releasing, and several additional self-released recordings. DiStefano went on to compose music for film, television and video games.

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